Insulin

Mar. 1st, 2023 09:07 am
walkitout: (Default)
I’ve apparently been thinking about insulin a lot lately!

Anyway.

I learned today that Eli Lilly is going to reduce prices on some of its insulin products (I was over at WSJ; I’m not endorsing WSJ or suggesting you read it, but here’s what I saw: https://www.wsj.com/articles/eli-lilly-to-cut-prices-of-insulin-drugs-by-70-c554f516). I was amused that in a heist episode of The Equalizer, a point in the backstory of the reformed criminal who was Robin’s client was that he turned to crime in order to pay for his younger brother’s insulin after their parents died. (The Equalizer, Season 3, Episode 9, “Second Chance”)

Apparently, this is the point at which pharma concedes. When your pricing choices are a plot point in The Equalizer, when your corporate choices are used to make a criminal more sympathetic, it’s probably time to change your pricing choices.

ETA:

Unrelated to insulin, but also in WSJ today, an article about Young People wanting to drive manual transmission cars.

https://www.wsj.com/articles/manual-transmission-stick-shift-cars-929dc155

The article explicitly relates this to point-and-shoot cameras and vinyl records as a similar trend. AND hilariously, the end quote is from a young woman who is already tired of her manual BMW and plans to buy an electric BMW when she can afford to.

As a formerly young woman who when young thought a manual was cool to drive, I can only agree with this choice. It is _currently_ still useful to know how to drive a manual when renting cars in some other countries. And also, I don’t expect that to last forever, either.

Good times. Young people being retro, and figuring out why we decided those things actually were not worth keeping around is in fact a core component of how our decisions are solidified after being double and triple checked.
walkitout: (Default)
Here’s an odd one.

https://www.science.org/content/article/war-prediabetes-could-be-boon-pharma-it-good-medicine

I have some mixed feelings about this. It quotes John Ioannidis favorably, and during the pandemic he was pretty vocal in ways that people got pretty mad about and I just don’t know what to think of him.

I was kind of startled by this paragraph:

“A 2011 study in JAMA examined health outcomes in women living in stressful, low-income housing projects who had been randomized into three groups: One got a voucher for better housing and help moving, one a voucher for moving to any area without help, and a control group got neither. Women who got the most housing assistance suffered the least obesity and diabetes—over 20 years, about 15% had become diabetic, compared with 20% in the control group.”

I landed in this article because I got curious about old people (>80 years of age, come on, that is old, don’t argue with me) taking diabetes medication that they did not need (that doctors had told them they did not need). I had heard about a friend’s father doing this, and then I recently learned that I knew someone more closely related to me who was doing this. I wondered if this was common and tried to design a search to answer the question, failed, but ran across interesting other things such as this.

I guess we really should focus on housing first.

Also, I ran across one of those cool Danish studies about olds taking diabetes medication, when (if) they discontinued, when they died, lots of interesting statistics.

Basically, if you are taking medication for your diabetes or prediabetes or whatever, it is in hopes of benefiting about 7 years in the future from reduced risk of wtf. If you are over 75, it’s not clear whether there is any hope of there being such a benefit, and if you are well into your 80s, the odds are very much against living long enough to enjoy it, even if there would be one if you did.

I gotta say, revelatory. I love shit like this. Perspective is all.
walkitout: (Default)
https://www.wired.com/story/the-teeny-tiny-scientific-screwup-that-helped-covid-kill/

A friend pointed me at that.

I’ve been doing a lot of thinking over the last year and almost a half. Every step of the way, uncertainty has made decision making hard and confidence impossible. On display has been all the things people do to find comfort in the midst of uncertainty and when feeling a lack of confidence in their own decisions.

I had, over the years, seen a lot of versions of the It Spreads By Touch theory, and mostly thought it was bunk. But people were really sure of it, so, you know, *shrug*. It’s nice to see that someone has tracked that particular error to its birth. The story if reminiscent of Antibiotics and Ulcers (there was this one idiot who completely destroyed all knowledge of the efficacy of abx against ulcers for like, 40 years, until the Aussies finally got that point through again). It is _also_ reminiscent of the Cancer Is Not Contagious / Cancer is Not an Infectious Disease Process (again, absolute bullshit). These bits of unproven (because you _can’t_ prove them — they are false!) certainty that are weaponized against marginal participants in academia and public institutions and which persist until either the perpetrator dies or a crisis forces people to change tack. But in this case, it took All Of the Above, because institutions. Maybe reinventing the wheel, maybe losing institutional memory is not the Bad Thing I tend to think it is.

It’s a lot smoother all around when, I’m Looking at You Not-A-Planet Pluto, the perpetrator of the bunk dies. Shouldn’t we be looking at _why_ the people who push this crap live so long, tho? I feel like they epitomize so much about longevity: you’ll live long if you have energy, and satisfying work, and power over others.

But if you have energy and satisfying work and power over others, you are probably going to do a lot of damage. Loyalty to that, to the institutions that can behave like the individuals, is really a problem.

As nice as it has been to have so many wonderful clean, public spaces as a result of persistently worrying about touch transmission, when airborne was our reality, I would rather we had spent the time and energy on better ventilation _and clear documentation of same_. I’ll be paying attention to upcoming flu seasons to see if I can tell whether ventilation really was improved; if it was, we may be reaping the benefits of that for decades to come.
walkitout: (Default)
You are probably trying to avoid the news, so following this link right now could lead to problems for you.

https://www.nytimes.com/2020/10/27/health/meth-addiction-treatment.html

I will summarize in detail instead! OK, basically describe the underlying thing and sprinkle with my own opinions.

There is a thing called “contingency management” for treating addiction. If you are treating opioid addiction, medication management is the gold standard, but not for people who have trouble with stimulants, especially meth. If you have any familiarity with incentives, you know some of the following:

(1) Incentives can be “intrinsic” or “extrinsic”. “Intrinsic” incentives are good-feelings produced by something inherent in the action / behavior / activity. For example, if you love looking at a completed jigsaw puzzle, then this is an “intrinsic” reward for doing jigsaw puzzles. If someone pays you for doing a jigsaw puzzle (or cooks you dinner in exchange for helping with a jigsaw puzzle, or praises you for doing a jigsaw puzzle), this is an “extrinsic” incentive or reward.

(2) Contrary to literally everything you have ever heard about good parenting, uncertainty of extrinsic rewards makes them way more effective as incentives. If literally _every single time_ you feed the dog, your parent says, “You are a good boy, Johnny”, then the day the parent does not say that is the day you stop feeding the dog. But if your parent says, “You are a good boy, Johnny”, about 1 our of 3 times you feed the dog, and it is not predictable (like you sometimes get it twice in a row, and sometimes you go 5 times without hearing it), you will _never_ stop feeding the dog and you might get a new dog when the dog dies, in hopes that the parent will say you are a good boy, and you might even keep trying to get the good boy after you have moved out and/or the parent has died.

(3) Whenever people receive extrinsic rewards for an activity, whether it is consistent or inconsistent and _even if they originally did the activity for intrinsic reasons_, they tend to stop. So, if you turn your hobby into a job, and then quit getting paid, you will probably NOT go back to doing it as a hobby (there are exceptions). If you quit using meth because you are getting paid (unevenly) for not using, then when you quit using, you are at very high risk of relapse.

Some genius figured, hey, let’s set up some erratic extrinsic rewards for people passing their drug test / showing up for therapy or group / getting detoxed, etc. One version involves pulling pieces of paper from a bowl. Some say, “You are a good boy, Johnny”, some are $1, $10, $25, whatever. Usually, it is not cash cash, but constrained cash (card usable at a certain group of coffee shops in the facility, or one of those EBT type cards that does not let you buy alcohol or whatever with it. Maybe it is coupons for free egg mcmuffin or whatever.

Lots of people have lots of issues with this, and an obvious one is, while people do show up for their therapy, and they start to get the intrinsic benefits of therapy / group / whatever, an awful lot of people relapse when the extrinsic (money) rewards stop entirely. OTOH, keeping them going forever would probably be cheaper than what we do with these kinds of people, so there are people in favor of permanently instituting this as a recovery management tool.

I think the whole thing is pretty interesting, and since AA thinks you should go to AA meetings forever, and people on methadone are expected to be on methadone forever, and in general, people need money to live, contingency management (compensating people with really serious meth issues) seems like an entirely plausible strategy to me. I mean, we gotta eat to live, and people with Borderline Personality Disorder are expected to need maintenance therapy forever and all that is more expensive than this. If you want people to show up to take their drug test, paying them to do so is one of the cheapest ways of getting them to be there (arresting them and/or assigning someone and paying that person to track them down and drag their ass in are all more expensive). If on top of that, paying them erratically can get them to take the drug test _and not use drugs so they test negative_, well, bonus!
walkitout: (Default)
It seems like we keep having to revisit this, and I am not sure why. It took a while to realize we really should test blood before transfusing it. It took a while to make sure that we were testing body parts (like cadaver gum tissue) before transplanting them. I mean, this seems pretty obvious by now. But, no, we are still rediscovering that this is an issue.

https://arstechnica.com/science/2019/06/killer-poop-fecal-transplant-patients-death-prompts-fda-to-push-out-warning/

Surprise: you need to test the poop before transplanting it. Because, it came from a human. And humans have cooties. Now, in the poop case, you want some of the cooties. But some of the cooties you do not want. Testing!

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